The pore sizes of porous β-tricalcium phosphate (β-TCP) affect bone-like cells. In this study, two different sizes of porous β-TCP granules, namely 300–600 μm and 600–1000 μm, were fabricated using sodium chloride (NaCl) powder as a porogen. This production was by mixing the different amounts of NaCl powder together with dry powder of dicalcium phosphate dihydrate (DCPD) and calcium carbonate (CaCO3) in the ratios of 10:90, 20:80, 30:70, and 40:60 (by wt%), respectively. Then, the NaCl powder have been removed after being subjected to a sintering process. This research produces different pore sizes of porous β-TCP granules. The four different average pore sizes, ranging from 2.8–3.6 μm, 4.9–5.5 μm, 6.9–7.0 μm, and 7.5–7.7 μm, were achieved by varying the amount of NaCl powder used. Furthermore, the confirmation of morphology, phase composition, and chemical structure of the fabricated granules was through different techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FTIR). The granules had a uniform and interconnected porous structure with different pore sizes, as revealed by SEM images, XRD and FTIR analyses, which proved the production of the porous β-TCP phase. This study finding shows that the tuneable pore sizes of porous β-TCP granules produced through a simple and low-cost method could have applications in bone tissue engineering.

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Tuneable Porous β-Tricalcium Phosphate Granular Fabricated Using Sodium Chloride Powder as Porosity Agent

  • Ahmed Hafedh Mohammed Mohammed,
  • Khairul Anuar Shariff,
  • Mohamad Hafizi Abu Bakar,
  • Hasmaliza Mohamad

摘要

The pore sizes of porous β-tricalcium phosphate (β-TCP) affect bone-like cells. In this study, two different sizes of porous β-TCP granules, namely 300–600 μm and 600–1000 μm, were fabricated using sodium chloride (NaCl) powder as a porogen. This production was by mixing the different amounts of NaCl powder together with dry powder of dicalcium phosphate dihydrate (DCPD) and calcium carbonate (CaCO3) in the ratios of 10:90, 20:80, 30:70, and 40:60 (by wt%), respectively. Then, the NaCl powder have been removed after being subjected to a sintering process. This research produces different pore sizes of porous β-TCP granules. The four different average pore sizes, ranging from 2.8–3.6 μm, 4.9–5.5 μm, 6.9–7.0 μm, and 7.5–7.7 μm, were achieved by varying the amount of NaCl powder used. Furthermore, the confirmation of morphology, phase composition, and chemical structure of the fabricated granules was through different techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FTIR). The granules had a uniform and interconnected porous structure with different pore sizes, as revealed by SEM images, XRD and FTIR analyses, which proved the production of the porous β-TCP phase. This study finding shows that the tuneable pore sizes of porous β-TCP granules produced through a simple and low-cost method could have applications in bone tissue engineering.