Electron Biological Imaging Centres at the SR Facilities: Diamond, ESRF, Soleil and SSRL/SLAC as Examples
摘要
As particle preservation techniques at cryo-temperatures improved, as well as the sensitivity of detectors, and their time-resolution, to the electrons transmitted through the single particles improved, the spatial resolution achievable with electron microscopy took a revolutionary leap to the atomic level. This was about ten years ago. There is an interesting restriction that the macromolecules or their complexes need to be a certain size such as above 100 kDa, depending on the spatial resolution achieved.