Founded by the will of Cardinal Mazarin, the college of the same name, also called the Collège des Quatre-Nations, was the only full college of the University of Paris to have a chair of mathematics. Pierre Varignon was the first holder from 1688 to 1722. Until the college was closed in 1793, four incumbents succeeded him : Leonor Caron, Nicolas-Louis de La Caille, Joseph-François Marie, and Pierre-Francois Chauveau. With Antoine-Sylvestre Lacroix, professor of mathematics at the short-lived École des Quatre-Nations, there are only six professors who, for a little more than a century, taught at the largest Parisian college and who, among a multitude of anonymous people, produced some great names in science and mathematics, such as D'Alembert or Legendre. Does the functioning of the college, the personality of the professors and the career of the students give the Mazarin college a special place in the history of the teaching of mathematics, or does this apparent specificity depend only on the personality of a few exceptional figures, in the forefront of which is Varignon?