Globally, cardiovascular disease is the leading cause of death to this date. After an infarction, scar tissue forms because of the incapacity of the heart to heal, which causes the heart malfunction. Therefore, research on heart regeneration is continually in demand. Thanks to the advances in stem cells and biomaterials of the advanced biological tissue design and regeneration medicine, there are promising ways for the engineering of substitute tissues for the cardiovascular system, which may work like the native tissue. Among all types of biomaterials, plant-derived materials have the highest propensity to support cell development because of their mechanical strength, bio composites and inherent biocompatibility. Additionally, compared with common As for the ones derived from plant sources, while collagen and gelatine are perhaps the most commonly derived from animals, they possess substantially fewer immunological properties. Better wettability is another benefit they provide over synthetic fabrics. There is currently a dearth of literature that provides a systematic overview of the development of biomaterials derived from plants for cardiovascular tissue regeneration. The current chapter and analysis highlight the most popular plant-derived biomaterials gotten from both terrestrial and aquatic plants. A fatigue of debate follows on the beneficial properties of these substances in mending damaged tissue. Nonetheless, as summarised using the up-to-date preclinical and clinical evidences, the potential use of plant-derived biomaterials within therapeutic cardiovascular tissue engineering-the tissue engineered scaffolds and the plant derived bio-inks in the course of 3D bio fabrication technique and the bioactive plantation for pharmaceutical utilization-are also briefly incorporated.