Green biomaterials have emerged as attractive and competitive alternative options in the fields of biomedical implants and tissue engineering. Biomaterials find extensive applications in supporting, enhancing, restoring, or replacing damaged tissues and organs within the human body. Furthermore, they maintain continuous interaction with the human body. Developing multifunctional green biomaterials that are compatible with human physiology is essential for achieving the necessary biological function while minimizing negative biological responses. The exploration of green biomaterials is gaining momentum in response to growing global concerns about environmental sustainability. This research area focuses on harnessing natural, renewable resources to create groundbreaking green biomaterials. The development of sustainable biomaterials encompasses the entire lifecycle of materials, considering factors such as desired properties, environmental impact during production, and strategies for recycling or disposal. This study shows an overview of the latest developments in synthetic and natural biomaterials covering their preparation, uses, potential applications, and future challenges in biomedical implants and tissue engineering applications. This study aims to guide designing future research, emphasizing the critical importance of selecting green multifunctional biomaterials to achieve optimal performance in biomedical implants and tissue engineering.