The quest for sustainable solutions in biomedicine has driven the creation of cutting-edge platforms that use eco-friendly nanocomposites for delivering genetic vaccines. This book chapter explores the potential of sustainable nanocomposites as advanced platforms for genetic vaccines, emphasizing their eco-friendly nature and promising applications in modern medicine. Researchers are paving the way for efficient and sustainable vaccination strategies by utilizing nanocomposites, which offer benefits like improved stability, precise release mechanisms, and focused delivery. This chapter delves into the design, synthesis, and characterization of sustainable nanocomposites, highlighting their biocompatibility and biodegradability. Additionally, we explain how integrating genetic material into these nanocomposites enables precise modulation of immune responses, opening new avenues for personalized medicine and disease prevention. This chapter seeks to motivate biomedical researchers and practitioners by thoroughly examining the latest progress and upcoming opportunities, encouraging the use of sustainable nanocomposites in the creation of next-generation genetic vaccines, thereby promoting a greener and healthier future.