Preimplantation genetic testing is now available in many countries. It is a fast-developing area as more and more of the genetic mutations that result in inherited genetic disorders can be detected. Some countries are actively seeking to expand the test to a wider range of conditions. This can raise both ethical and legal issues. How can we decide which condition has a sufficiently serious impact on a person’s life to include? Does availability of the test diminish the value of lives with a disability? There arises the issue of eugenics. Different countries in the world have various forms of regulation. This chapter discusses the approaches by these countries.