Counterfeit drugs pose a substantial threat to public health and the integrity of the pharmaceutical supply chain. Addressing this threat necessitates innovative solutions that ensure product authenticity, patient safety, and industry integrity. The integration of blockchain technology with various advanced tools has emerged as a promising avenue to tackle this challenge effectively. This paper presents a comprehensive survey on the utilization of blockchain-integrated technologies for combating counterfeit drugs. Through the convergence of blockchain’s core attributes such as transparency, immutability, and decentralization, along with the capabilities of other cutting-edge technologies, such as automated compliance management through smart contracts, real-time monitoring via the Internet of Things, and data-driven insights derived from Artificial Intelligence, a secure and traceable ecosystem can be established. By surveying existing blockchain-based initiatives in counterfeit drug detection and proposing an encompassing approach to address limitations, this paper sheds light on the potential transformative impact of these integrated technologies. ...