The escalating concerns of environmental pollution and the diminishing efficacy of synthetic nematicides demand sustainable alternatives for managing plant-parasitic nematodes, particularly the root-knot nematode (Meloidogyne incognita). This chapter explores the potential of nanofertilizers as a dual-pronged strategy for promoting plant growth and controlling nematode infestations. We delve into the diverse sources of nanofertilizers, and their mechanisms of action against nematodes. This chapter evaluates the biological activities of nanofertilizers as nematode management candidates, highlighting their mechanisms of action their abilities to enhance plant growth, accumulation inside plants, and possible phytotoxic and environmental risks.