The large-screen and multi-screen design of the HMI (Human-machine interface) is one of the essential manifestations of today’s intelligent cabins. However, this trend poses a risk of distracting drivers and affecting safe driving. We used VR (Virtual Reality) technology to provide participants with a simulated driving environment and used eye movement analysis to explore the impact of the total size of the front HMI in intelligent cabins on the drivers’ eye movement behavior. At the same time, we investigated the effects of driving age, driving time, and whether the cabins are equipped with a HUD (Head-up Display) on the driver’s eye movement behavior. The results indicated that the total size of the HMI had a significant impact on the drivers’ eye movement behavior, and the larger the total size, the more distracting the drivers’ attention. The three variables of driving age, driving time, and whether or not a HUD is used had no significant impact on the eye movement behavior of drivers.