With the advancement of aerospace technology, space travel is becoming increasingly accessible. However, motion sickness in the microgravity environment poses a significant challenge, especially for non-professionally trained space tourists. Motion sickness symptoms, primarily caused by mismatches between visual, vestibular, and somatosensory inputs, are exacerbated in weightlessness. This study leverages virtual reality (VR) technology to develop a desensitization training method that simulates the sensation of space motion sickness. By emulating space environments and motion sickness, the method enhances users’ resistance to dizziness through engaging in VR games. The effectiveness of this training was initially validated through the design and implementation of the Space Balance VR game. Vestibular function tests conducted using the NeuroCom Balance Manager System indicated a significant reduction in motion sickness symptoms among participants, with notable improvements in vestibular and visual resistance to dizziness. This study not only preliminarily confirms the potential of VR technology in motion sickness training but also offers a new adaptive training approach for the general public and future space travelers.