This systematic literature review critically examines 48 carefully chosen articles to delve into the complexities of Blockchain technology risks and vulnerabilities. The research covers a wide range of topics, including supply chain performance, financial security, risk analysis and optimization in the Blockchain era, and the relationship between this technology and other cutting-edge fields like artificial intelligence and the Internet of Things. The security of smart contracts, supply chain management, financial risks, and the interaction of Blockchain technology with cutting-edge fields like artificial intelligence and the Internet of Things are given particular attention. The analysis points out particular details about vulnerabilities, like security holes in smart contracts and the possibility of attacks taking advantage of logical weaknesses. It also examines the inherent risks associated with deploying Blockchain in different industries, illuminating best practices and strategies for mitigation. By combining these results, the review not only advances our knowledge of the threats and vulnerabilities that exist in Blockchain technology today, but it also establishes itself as a useful tool for experts, scholars, and decision-makers attempting to understand the intricacies of this game-changing innovation.