Laparoscopic pancreatoduodenectomy (LPD) has evolved over the past two decades thanks to the pioneering vision of dedicated surgeons and the continuous advancements in surgical technology. To date, four randomized controlled trials have contributed to our understanding of its efficacy. LPD has emerged as a technique achieving short-term outcomes comparable to the open approach while improving patient comfort. These benefits include reduced hospital stays, fewer readmissions, improved gastric emptying, diminished postoperative pain, and decreased use of pain medication. Propensity scores matching analyses have indicated that LPD may yield negative resection margin rates and number of dissected lymph nodes comparable to those of the open approach. However, the determination of long-term and oncological outcomes of LPD necessitates further rigorous investigation including randomized data. This chapter presents a minimally invasive approach to LPD, characterized by its reproducibility yet demanding advanced laparoscopic skills. Twenty-two surgical steps are meticulously outlined to offer a comprehensive guide to this procedure. Furthermore, it encapsulates the authors’ experiences, aiming to optimize the safety, reproducibility, and efficiency of this complex operation.