In this chapter, we explore the emergent practices of strategic and systemic design within and across a landscape usually dominated by technology-led design and development traditions. Describing the shifting relationships within and around these technology-oriented design practices, and the systemic challenges they are embedded within, we explore how their relatively narrow perspectives might be enriched and expanded by recognising the social, cultural and environmental contexts of technology. In particular, we draw on questions of urban technology and design for living environments. We use ‘the city’ and its interconnected systems, and requirements for civic common good outcomes, to open up and extend the idea of ‘human-technology interaction’ (HTI), via a new systemic design concept of ‘Place Layers’. We consider the interplay between public, private and third sector actors in shaping the trajectory of technological progress, as well as the corollary: the impact of technologies on governance, organisation, policies and practices. This broader context of HTI moves the field beyond reductive understandings of ‘human’, ‘technology’ and ‘interaction’: an expanded practice of HTI must include the more-than-human, a diversified reading of what technology is, and systemic relationships rather than merely individual interactions. We argue that strategic design is one example of such an extended practice in its ambit and ambition, helping to navigate the complex, interconnected relationships between evolving technologies, infrastructures and living environments, and our shared societal and environmental systemic challenges, and that this offers a pivotal and necessary set of emerging relationships with human-technology interaction accordingly.