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• Mutations in the breast cancer 1 or 2 tumor suppressor genes (BRCA1/2) are responsible for the majority of inherited breast and ovarian cancers.   – BRCA1 is located on chromosome 17; BRCA2 is located on chromosome 13.   – It has an autosomal-dominant pattern of inheritance.   – <10% of breast cancers are hereditary.  • Those with BRCA1/2 mutations have a greater frequency of bilateral breast cancer and a younger age of onset of cancer.  • The mutation is common in those of Ashkenazi Jewish descent (risk is 30–35%).

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Hereditary Breast Cancer (BRCA1/2)

  • 章节

  • 发表日期：

    2025年

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  • Carly Wareham,
  • Salvatore Nardello

摘要

• Mutations in the breast cancer 1 or 2 tumor suppressor genes (BRCA1/2) are responsible for the majority of inherited breast and ovarian cancers.   – BRCA1 is located on chromosome 17; BRCA2 is located on chromosome 13.   – It has an autosomal-dominant pattern of inheritance.   – <10% of breast cancers are hereditary.  • Those with BRCA1/2 mutations have a greater frequency of bilateral breast cancer and a younger age of onset of cancer.  • The mutation is common in those of Ashkenazi Jewish descent (risk is 30–35%).