• Acute pancreatitis results from acinar cell injury secondary to the autodigestive properties of inappropriate trypsin release, leading to a spectrum of illness ranging from short, self-limited episodes of pancreatitis to a debilitated chronic condition (Lankisch et al., Lancet 386(9988):85–96, 2015; Rayman et al., Am Surg 89:4817, 2023). • The most common cause of acute pancreatitis is biliary etiology (Mederos et al., JAMA 325(4):382–390, 2021). • Diagnosis of acute pancreatitis is based on the Revised Atlanta Criteria (Colvin et al., Abdom Radiol (NY) 45:1222–1231, 2020). These criteria also classify the disease into morphologic subtypes and describe peripancreatic fluid collections. • Initial management of acute pancreatitis, regardless of etiology, includes fluid resuscitation, close monitoring, and optimal nutrition. • In patients with mild-moderate gallstone pancreatitis, cholecystectomy is recommended during index admission to reduce risk of recurrent pancreatitis (Crockett et al., Gastroenterology 154:1096–1101, 2018). For patients with necrotizing gallstone pancreatitis, it is recommended to wait 8 weeks for cholecystectomy with consideration of preoperative imaging (Hallensleben et al., Gut 71(5):974–982, 2022). • Early peripancreatic fluid collections should be managed without intervention regardless of etiology. The primary indication for intervention is underlying infection, though may be considered in patients with persistent symptoms, failure to thrive, etc. • Intervention for peripancreatic fluid collections in necrotizing pancreatitis should be based on the local institutional resources, anatomic location of the collection, and the specific clinical scenario. Options include minimally invasive Step-Up approaches and transgastric debridement (van Santvoort et al., N Engl J Med 362(16):1491–1502, 2010; van Brunschot et al., Lancet 391(10115):51–58, 2018; Maatman and Zyromski, J Gastrointest Surg 25:331–332, 2021).