Urethritis is characterized by inflammation of the urethra, typically presenting symptoms such as dysuria and urethral discharge. The primary pathogens associated with urethritis include Neisseria gonorrhoeae and Chlamydia trachomatis. When these pathogens are excluded, the condition may be classified as nongonococcal urethritis (NGU) or nongonococcal nonchlamydial urethritis (NGNCU). Other potential causative agents include mycoplasma and herpes simplex virus. Diagnosis is based on the analysis of urethral discharge, urine, and smears, with the identification of granulocytes in the smear serving as an indicator of urethritis. Immediate initiation of antibiotic therapy is recommended. If symptoms persist, reevaluation is warranted, as recurrent or persistent urethritis may suggest the involvement of other pathogens or resistant organisms. When symptoms are present without isolation of a pathogen, often accompanied by burning and itching, specialized clinical examinations should be conducted, and individualized treatment should be implemented.