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This paper evaluates various deep learning methods for measurable residual disease (MRD) detection in flow cytometry (FCM) data, addressing questions regarding the benefits of modeling long-range dependencies, methods of obtaining global information, and the importance of learning local features. We propose two adaptations to the current state-of-the-art (SOTA) model based on our findings. Our contributions include an enhanced SOTA model, demonstrating superior performance on publicly available datasets and improved generalization across laboratories, as well as valuable insights for the FCM community, guiding future DL architecture designs for FCM data analysis. The code is available at https://github.com/lisaweijler/flowNetworks .

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On the Importance of Local and Global Feature Learning for Automated Measurable Residual Disease Detection in Flow Cytometry Data

  • 会议论文

  • 发表日期：

    2025年

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  • Lisa Weijler,
  • Michael Reiter,
  • Pedro Hermosilla,
  • Margarita Maurer-Granofszky,
  • Michael Dworzak

摘要

This paper evaluates various deep learning methods for measurable residual disease (MRD) detection in flow cytometry (FCM) data, addressing questions regarding the benefits of modeling long-range dependencies, methods of obtaining global information, and the importance of learning local features. We propose two adaptations to the current state-of-the-art (SOTA) model based on our findings. Our contributions include an enhanced SOTA model, demonstrating superior performance on publicly available datasets and improved generalization across laboratories, as well as valuable insights for the FCM community, guiding future DL architecture designs for FCM data analysis. The code is available at https://github.com/lisaweijler/flowNetworks .