In addition to presenting with core features of autism spectrum disorder (ASD), children with ASD also require routine medical care and, at times, emergency or hospital-based care for medical conditions. While some medical care for autistic individuals has been deemed evidence-based, many of the guidelines that exist for primary care or hospital-based clinicians are developed through clinical consensus. This chapter will review common co-occurring medical and behavioral health conditions associated with ASD as well as the evidence-based practices or clinical consensus guidelines that exist for managing those associated symptoms. Evidence-based resources that specifically aim to support clinicians in the medical setting are also included.