Nanofertilizersplay a keyrole in augmenting plant’s stress-tolerance. As an integral part of contemporary agricultural practices, nanofertilizers exhibit unique properties at the nanoscale, influencing plant responses to diverse stressors such as drought, salinity, and nutrient deficiencies. Nanofertilizers have the ability to improve plant uptake and utilization of nutrients, as well as their ability to withstand abiotic stressors. They can also act as a carrier for the delivery of other beneficial compounds, such as pesticides and fungicides. Through a comprehensive exploration of the current state of research and practical applications, this chapter elucidates the underlying mechanisms by which nanofertilizers enhance stress tolerance. The discussion encompasses molecular and physiological changes, shedding light on nanofertilizers’ potential to optimize nutrient utilization efficiency, fortify antioxidant defenses, and modulate stress-responsive gene expression. Furthermore, the chapter evaluates the environmental implications and sustainability considerations associated with nanofertilizer deployment, offering insights into the future trajectory of this innovative approach in promoting resilient crop production.