Artificial intelligence is considered as most breakthrough technology nowadays with primary subdivisions machine learning and deep learning. Artificial intelligence enabling digital entities not only to learn but also to gain and optimize knowledge to the manifold of possible applications in essential and important smart environmental domains. This includes, but is not limited to control and optimization of many kind of smart systems like cities, energy, financial, home, medical, traffic, and others with exiting solutions, never seen before. Unfortunately, an emerged growth can be seen for cybercrime, conducted by cyber-threat attacks based on AI-system applications, which has a negative endeavor due to cybersecurity risks. However, AI can also be used to defend against cybercrime activities, which has a positive endeavor making AI-based systems cyber-secure. Given this fact, the objective of this chapter is to introduce into both aspects, using AI methods to detect and defend against cybercrime. Finally, a practical example illustrates how AI can be successfully applied in the smart environment sector.