Citrus Processing Waste (CPW), a significant byproduct of the citrus industry, presents both environmental and economic challenges due to its high organic content. Traditionally utilized as animal feed or organic soil conditioner, recent advancements have broadened its application through valorization strategies, transforming CPW into valuable products such as biofuels, bioactive compounds, and biomaterials. This chapter explores innovative and sustainable techniques for the valorization of CPW, emphasizing their impact on food safety, economic viability, and environmental sustainability. It discusses the utilization of green technologies such as microwave-assisted and ultrasound-assisted extractions, which enhance the efficiency of compound extraction while adhering to green chemistry principles. The comprehensive application of these technologies not only mitigates the environmental impact of citrus waste but also contributes to a circular economy by creating valuable resources from waste materials. Additionally, the chapter addresses the challenges and future perspectives in the CPW valorization, highlighting the necessity for ongoing research and development to optimize these processes and expand their applications. Through a detailed exploration of case studies and practical applications, this chapter illustrates the transformative potential of CPW, offering insights into its role in promoting a sustainable bioeconomy and enhancing global food security.