The chapter “Innovation Culture: How to Empower Employees for Innovation?” addresses the alarming decline in innovation within German companies, which has significantly impacted their competitive advantage and profitability. The chapter emphasizes that innovation is driven by individuals within organizations, not solely by organizational structures or leadership. It highlights the negative attitudes prevalent in the workforce toward innovation, which are exacerbated by the rapid pace of digitalization and economic challenges. The chapter introduces the concept of an open innovation (OI) mindset as a crucial factor for enhancing innovation capabilities. Drawing on the theory of planned behavior, it suggests that fostering a positive attitude toward knowledge sharing and sourcing is essential for successful innovation. The chapter explores how organizations can systematically cultivate an OI mindset through collaborative human resource management practices, digital tools, and incentive systems. Two case studies illustrate the practical application of these concepts. The OMIND software is presented as a digital tool designed to embed innovation habits into daily work routines, promoting a sustainable cultural transformation. The case studies demonstrate how companies can empower their employees, enhance collaboration, and achieve measurable improvements in innovation performance by adopting a holistic approach to innovation culture. In conclusion, the chapter underscores the importance of aligning individual mindsets, leadership styles, and organizational incentives to create a thriving innovation culture that drives long-term business success.