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The thymus is an essential component of the immune system responsible for producing T cells. It is anatomically divided into two main regions: the outer cortex and the inner medulla. This chapter summarizes our current understanding of thymic stromal cell functions, with a particular focus on the interactions between these cells and T cells. This exploration aims to shed light on the pathogenesis of immune disorders, including autoimmunity.

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The Ins and Outs of Thymic Epithelial Cell Differentiation and Function

  • 章节

  • 发表日期：

    2025年

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  • Minoru Matsumoto,
  • Francisco Sobral,
  • João S. Cardoso,
  • Takeshi Oya,
  • Koichi Tsuneyama,
  • Mitsuru Matsumoto,
  • Nuno L. Alves

摘要

The thymus is an essential component of the immune system responsible for producing T cells. It is anatomically divided into two main regions: the outer cortex and the inner medulla. This chapter summarizes our current understanding of thymic stromal cell functions, with a particular focus on the interactions between these cells and T cells. This exploration aims to shed light on the pathogenesis of immune disorders, including autoimmunity.