The cancer care system suffers from unevenly distributed resources, variability in practice, workforce constraints, and misaligned financial incentives. A quality cancer care system is equitable, patient-centered, safe, effective, and timely. Attaining this vision of quality care depends on a collaborative commitment to equity, transparency, and information sharing for ongoing quality improvement. This chapter focuses primarily on quality cancer care in the USA with implications for global expansion and attention to the navigator role in quality cancer care.