Deep venous thrombosis (DVT) and pulmonary thromboembolism (PTE) are known and severe postoperative complications and major cause of morbidity and mortality up to 1 year after bariatric surgery. Patients undergoing bariatric surgery should be considered at least at moderate risk for DVT and PTE, and pharmacologic prophylaxis reduces the incidence of these thrombotic complications. Portomesenteric vein thrombosis (PVT) is a rare and potentially life-threatening postoperative complication in bariatric surgery with a higher incidence after laparoscopic sleeve gastrectomy (LSG) compared with other bariatric procedures. Extended postoperative pharmacologic prophylaxis reduces the incidence of DVT and PE, may also reduce the incidence of PVT, and should be considered in patients after LSG.