Recent advances in technology and surgery have significantly expanded the options for restoring functionality in individuals with upper limb amputations. Maximizing the benefits of these advancements necessitates a multidisciplinary approach, wherein rehabilitation professionals such as physiotherapists and occupational therapists play a crucial role. The aim of this chapter is to provide an overview ofindications for therapy in specific interventions aimed to facilitate the optimal use of advanced prosthetic devices. General rehabilitation components encompass patient education, pain management, addressing movement restrictions, enhancing muscle strength and endurance, and correcting postural issues. Additionally, specialized interventions such as surface electromyography-based muscular activation training in selective nerve transfers and gradual loading protocols for bone-anchored prostheses are discussed to ensure successful patient outcomes.