A decreased hand strength is a common problem in various patient populations. The Carbonhand system is a wearable soft-robotic glove that supports patients’ hand function while performing daily activities. To assess the usability and satisfaction of the next generation of Carbonhand, a usability study with five patients with persistent hand function limitations due to trauma or arthritis was conducted. Although several usability issues were identified, usability scored positive on the System Usability Scale. Glove satisfaction was positive, control unit satisfaction was slightly lower. The current findings highlight that usability testing is important for further optimization of assistive devices, with the ultimate goal of promoting technology adoption by potential end users.