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Repetitive transcranial magnetic stimulation (rTMS) has been extensively used to modulate cortical excitability and treat neurological disorders. However, the extent to which rTMS is effectively transmitted to spinal motor neuron output remains unexplored. In this study, we investigated the corticospinal transmission of various rTMS frequencies to motor unit activity. Eight participants performed low-level isometric contractions of thumb flexion while rTMS pulses were delivered to the primary motor cortex at 70% of the resting motor threshold. Stimulation frequencies of 5, 10, 20, 30 and 50 Hz were used. High-density surface electromyograms recorded from the thenar muscles were decomposed into motor unit spike trains, and the z-coherence between the rTMS stimuli (input) and the cumulative spike train (output) was calculated. Significant input-output coupling was observed at frequencies of 20 Hz and higher. These preliminary findings suggest that the efficiency of the transmission of the synaptic input generated by rTMS to the neural drive to the muscle is frequency dependent.

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Transfer Function of Spinal Motor Neurons in Response to Different Frequencies of Repeated Transcranial Magnetic Stimulation

  • 会议论文

  • 发表日期：

    2025年

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  • Hélio V. Cabral,
  • Milena A. dos Santos,
  • Andrea Rizzardi,
  • Marco Benedini,
  • Mikaël Desmons,
  • Elmira Pourreza,
  • J. Greig Inglis,
  • Maria Cristina Rizzetti,
  • Alessandro Padovani,
  • Andrea Pilotto,
  • Francesco Negro

摘要

Repetitive transcranial magnetic stimulation (rTMS) has been extensively used to modulate cortical excitability and treat neurological disorders. However, the extent to which rTMS is effectively transmitted to spinal motor neuron output remains unexplored. In this study, we investigated the corticospinal transmission of various rTMS frequencies to motor unit activity. Eight participants performed low-level isometric contractions of thumb flexion while rTMS pulses were delivered to the primary motor cortex at 70% of the resting motor threshold. Stimulation frequencies of 5, 10, 20, 30 and 50 Hz were used. High-density surface electromyograms recorded from the thenar muscles were decomposed into motor unit spike trains, and the z-coherence between the rTMS stimuli (input) and the cumulative spike train (output) was calculated. Significant input-output coupling was observed at frequencies of 20 Hz and higher. These preliminary findings suggest that the efficiency of the transmission of the synaptic input generated by rTMS to the neural drive to the muscle is frequency dependent.