Recent research has established a strong connection between oral health and 28 systemic noncommunicable diseases, emphasizing the critical role of oral and digital oral health interventions (teledentistry) in enhancing oral and systemic health. These early interventions are particularly relevant in managing cancer, cardiovascular and neurodegenerative diseases, systemic disorders, aging, and pregnancy. Saliva diagnostics and salivaomics, leveraging various biomarkers, are emerging as pivotal tools in routine diagnostics, offering insights into disease progression, noninvasive monitoring of chronic conditions, and personalized treatment strategies. The development of oral wearable biosensors for noninvasive salivary analysis, coupled with wireless communication and artificial intelligence, is revolutionizing the field by extending diagnostics from oral health to overall systemic health. Advances in digital health, including AI-powered teledentistry, enable continuous oral health monitoring via intraoral cameras and smartphones, improving clinical decision-making and treatment effectiveness. This integration fosters precision oral medicine and enhances patient-centered care, particularly in managing chronic diseases. Additionally, augmented reality is being utilized to address dental anxiety, benefiting children, patients with autism spectrum disorder, and adults with dental phobia. The advent of robotics in minimally invasive dentistry, alongside regenerative dentistry focused on tissue engineering and 3D bioprinting, promises a transformative future in dental care. These innovations are not only reshaping current dental practices but also holding potential for application in extreme environments, such as long-duration space missions.