Vascular involvement is seen in the range of 15–50% in Behçet’s disease (BD), commonly in males. Venous involvement consists of 67–84% among all vascular manifestations. Arterial involvement is seen less than 15%. Deep vein thrombosis (DVT) in lower extremities is the most frequent type of vascular involvement. PTS, which is the most frequent complication of DVT, is observed in up to 64% of BD with DVT. It causes impaired venous disease-associated QoL. Therefore, prevention of post-thrombotic syndrome (PTS) should also be targeted as well as prevention of relapses in daily practice. Pulmonary arterial involvement or Budd–Chiari syndrome (BCS) is the major cause of mortality in BD. Diagnosis of vascular BD depends on the presence of other clinical features of BD after excluding other potential reasons. Diagnosing BD can be difficult in patients presenting with only vascular involvement with or without oral ulcers. Recent studies showed that common femoral vein (CFV) thickness measurement can be a practical and cheap diagnostic tool for BD with the sensitivity and the specificity higher than 80% for the cutoff value of 0.5 mm. However, the diagnostic accuracy of CFV measurement should also be validated in different ethnic populations.