The lungs offer a (relatively) easy access route by inhalation for drug delivery, both in terms of topical therapy of lung conditions as well as for systemically acting therapies. In paediatric therapy, it is the former which has been most exploited for the delivery of agents such as bronchodilators, corticosteroids and antibiotics where localized drug delivery can minimize systemic exposure and resultant side-effects.

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The Challenges of Paediatric Pulmonary Drug Delivery

  • Darragh Murnane,
  • Laura Urbano,
  • Marc B. Brown

摘要

The lungs offer a (relatively) easy access route by inhalation for drug delivery, both in terms of topical therapy of lung conditions as well as for systemically acting therapies. In paediatric therapy, it is the former which has been most exploited for the delivery of agents such as bronchodilators, corticosteroids and antibiotics where localized drug delivery can minimize systemic exposure and resultant side-effects.