Nepal is highly prone to naturalUAV hazards where the frequency and magnitude of the occurrence of such events have been found to increasing in recent decades. DisasterDisaster risk reduction and management (DRRM)DRRM is of utmost necessity in this country to save lives and properties. While doing so, different forms of frontier technologies are being practiced for risk reduction. The Unmanned Aerial Vehicle (UAV)UAV has rapidly emerged as a promising and highly effective solution for facilitating data collection and enhancing service delivery across all stages of the disasterDisaster cycle, including prevention/mitigation, preparedness, response, and recovery. The complexities of the rugged topography, steep slopes, and difficult terrains in the Nepal Himalayas can be overcome through the versatility of drones as they serve as an easy solution for high-resolution aerial surveys that contribute to enhancing situational awareness. Moreover, drones are quickly deployable technology that can help capture the ground situation in detail over the monsoonal hotspots, and planning processes. The use cases regarding the use of drones after the Gorkha Earthquake 2015, the Drone Optimized Therapy System (DrOTS) project, high-resolution aerial mapping during the COVID-19 lockdown, and drones-based rapid damage assessment during Melamchi Debris Flow 2021 suggest how the drone technologies have been evolving for a transformation and paradigm shiftParadigm shift toward the adoption of Science, Engineering, Technology, and InnovationInnovation (SETI)SETI for DRRMDRRM. The adoption of SETISETI does take ample time, but with the availability of science and evidence-based approaches, the acceptance and willingness toward the change becomes evident. However, it is also important to understand the underlying constraints and barriers while deploying drones for effective DRRMDRRM.