When a soft tissue sarcoma (STS) is suspected—ideally prior to any invasive procedure—patients should be referred to the next sarcoma center. We should follow a standardized diagnostic approach, beginning with the patient history, clinical examination, and appropriate imaging prior to conducting biopsy. After this, a multidisciplinary team with surgeons, radiologists, pathologists, medical oncologists, and radiotherapist oncologists must decide the better combination of therapies for each specific case. Among the options, neoadjuvant therapy can help soft tissue sarcomas by decreasing the size and infiltration of the surrounding tissues, thus helping the surgeon in achieving safe wide surgical margins with better functional results. In this case, this aim was achieved, with a necrosis of 100% of the specimen and wide margins. Postoperative treatment was not necessary, due to the excellent results of the preoperative neoadjuvant approach.