As demand for sustainable and eco-friendly packaging grows, industries are studying biopolymers for food packaging. From the stage of conceptualization to the stage of consumer applications in the real world, this review paper focuses on novel combinations of collagen and a variety of natural biopolymers. It offers an in-depth analysis of the process. The review begins with collagen's biopolymer properties and then explores many natural biopolymers suitable for collagen fusion. By examining synergistic effects, the paper shows how each biopolymer improves blend performance. In this study, the influence of processing parameters on the formation of films as well as the mechanical, barrier, and thermal properties of collagen-natural biopolymer films is investigated systematically. The in-depth study includes food industry case studies and consumer perception and sensory attributes of collagen-natural biopolymer packaging. To understand this field's challenges and opportunities, regulatory and compliance issues are examined. To promote sustainable packaging, collagen-natural biopolymer films are evaluated for environmental impact and biodegradability. Cellulose is a promising natural biopolymer for food packaging applications due to its biodegradability, renewability, and excellent barrier properties. When combined with collagen, cellulose can enhance the mechanical strength and stability of the packaging material. Collagen-natural biopolymer films are compared to conventional packaging materials for performance, cost, and environmental impact. This review concludes with current research, challenges, and future directions in collagen fusion with natural biopolymers for food packaging. This review aims to inform researchers, industry professionals, and policymakers about sustainable food packaging.