Traditionally, treatment strategies for pediatric cancers relied heavily on surgery and radiotherapy, particularly for solid tumors. However, with the introduction of chemotherapy, many childhood cancers, especially hematological malignancies—have become more treatable with cytotoxic agents alone, leading to improved long-term outcomes with better quality of life [1–3]. Despite this progress, local control remains cornerstone of therapy, particularly for solid tumors where the risk of recurrence is significant if residual disease is left untreated.