Multidisciplinary team (MDT) care has been a cornerstone of the management of childhood cancer since the earliest development of pediatric oncology treatment protocols. In present times, the role and composition of the MDT has become more clearly defined, yet diversified, especially with the introduction of novel models of care and inclusion of allied health professionals in these teams. Yet, as MDT care systems develop further, operational issues and team dynamics can also become more complex. Currently, emerging standards for the establishment and function of pediatric cancer MDTs may help institutions benchmark their performance in delivering optimal team care. Peculiar considerations for MDT care exist in several unique settings, in particular, pediatric precision oncology MDTs, late effects and survivorship programs, MDTs in pediatric oncology clinical trials, and pediatric cancer care in low and middle-income countries (LMICs) – where issues of resource limitation, diagnostic challenges, and treatment abandonment are barriers to improved outcomes. Yet, early examples of successful implementation of MDT care in these contexts may provide keys to how the ideal principles of team care in childhood cancer can be optimally applied in varied ways.