Serious games and telerehabilitation are increasingly significant in the recovery process of neurological patients, and personalization and adaptivity in difficulty levels according to patients’ abilities are crucial characteristics. This paper describes a solution for managing the settings of a multiple-serious games platform (N-RehLab) for patients with neurological disorders, avoiding the specific configuration of each serious game separately. To this end, a serious game named Assessment Serious Game (ASG) has been developed. Its outcome is a unique index, with a value between 0 and 1, which assesses the patients’ capabilities based on parameters measured with a Leap Motion device. Using this index, the N-RehLab recommends a personalized rehabilitation program to medical personnel, specifying which serious games and the relative levels of difficulty the patient should engage with. A discussion on the developed solution is presented and improvements are identified to move towards clinical experimentation.