Fusarium is a multifaced genus composed of both devastating plant pathogens and beneficial fungi species. When Fusarium is not causing disease in plants, it is producing a wide array of structurally diverse and unique metabolites with potential application in various industries including agriculture. Metabolites produced by Fusarium have multidimensional bioactivities. In the agricultural system, they have been reported to affect plant health both directly and indirectly. Fusarium can produce molecules such as phytohormones for development, siderophores for iron acquisition, enzymes for nutrient mobilization and volatile metabolites that can function as signal molecules and play important roles in plant growth and development. Fusarium also produces non-volatiles and volatiles metabolites with ability to inhibit various phytopathogens and nematodes. Metabolites produced by Fusarium can also impact plant physiology and induce plant defense systems to resist against biotic and abiotic stresses. This chapter provides a brief overview of the beneficial and potential application of Fusarium metabolites for crops improvement.