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Nuclear Distribution Protein C (NUDC) has been studied extensively for its role in mitosis. In addition to its well-established role in dynein-mediated nuclear migration, NUDC also plays a role in postmitotic cells. NUDC affects dynein-mediated protein and organelle trafficking and also stabilizes the actin-modulating protein, cofilin (CFL1), thereby affecting cytoskeletal reorganization. This mini-review will cover the known role of NUDC in mitosis as well as its role in actin cytoskeletal reorganization and in protein and organelle trafficking in nondividing cells, as well as update findings on the effect of a loss of NUDC on rod photoreceptors.

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NUDC Is Critical for Mitosis and Postmitotic Cell Maintenance Through Its Modulation of Dynein and Actin Cytoskeletal Reorganization

  • 会议论文

  • 发表日期：

    2025年

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  • Mary Anne Garner,
  • Alecia K. Gross

摘要

Nuclear Distribution Protein C (NUDC) has been studied extensively for its role in mitosis. In addition to its well-established role in dynein-mediated nuclear migration, NUDC also plays a role in postmitotic cells. NUDC affects dynein-mediated protein and organelle trafficking and also stabilizes the actin-modulating protein, cofilin (CFL1), thereby affecting cytoskeletal reorganization. This mini-review will cover the known role of NUDC in mitosis as well as its role in actin cytoskeletal reorganization and in protein and organelle trafficking in nondividing cells, as well as update findings on the effect of a loss of NUDC on rod photoreceptors.