Methanol is regarded as one of the significant alternative energy sources for internal combustion engines, with the blending of nanoparticles aiding in the combustion process. This paper investigates the effects of different types of nanoparticles and various nanoparticle blending concentrations on the evaporation characteristics of methanol fuel droplets using a pendant drop evaporation experimental setup. The study divides the entire evaporation process of mixed droplets at an ambient temperature of 973 K into two stages: the fluctuating evaporation stage and the quasi-equilibrium evaporation stage. It was observed that the equilibrium evaporation stage of methanol blended with nano-fuels at 973 K follows the classical d2 law. Additionally, by analyzing the micro-explosion intensity and delay time of the droplets, a comparative analysis was conducted on the evaporation process of fuel droplets containing different types of nanoparticles. The results indicate that the addition of both types of nanoparticles promotes evaporation; however, as the mass concentration nanoparticles increases, their effect on the evaporation of fuel droplets first promotes and then inhibits the process. Among the nanoparticles, CNT exhibits a more significant enhancement of the fuel droplet evaporation process compared to Al2O3, with the best evaporation performance observed at a CNT concentration of 50–100 ppm.