Counterfeiting is a concerning issue that has drawn more attention from consumers, businesses, and governments. Preventing fraud and counterfeiting is getting more difficult due to globalization, complex supply chains, technological improvements, and rapidly changing customer behavior. Additionally, the growth of e-commerce facilitates the expansion of counterfeit goods. Blockchain technology (BC) can assist companies in preventing counterfeiting and fraud. This study offers practitioners and scholars fundamental knowledge about blockchain technology and its anti-counterfeiting features and applications. BC provides various unique features, including decentralization, immutability, security, privacy, transparency, and interoperability. As a result, this chapter provides an overview of a blockchain-based anti-counterfeiting architecture. Four dimensions are defined: customer involvement, supply chain collaboration, counterfeit reduction, and technology integration. Moreover, this chapter highlights organizational implications and difficulties when using BC. The chapter provides directions for future directions that encourage using BC to stop fraud and counterfeiting.