Gold mining holds significant strategic importance as the exploration of mineral reserves extends to deeper levels due to the discovery of shallower resources becoming more accessible. During the last four decades, listvenite associated with ophiolitic ultramafic rocks attracted many geologists worldwide because of the intimate relationship between listvenitization and gold mineralization. In many localities, e.g. in the Russian Urals and Turkey, it was noticed that native gold is formed during the transformation of the ultramafic precursor into listvenite especially when being confined to thrust planes. Numerous ultramafic masses are detected in the Eastern Desert of Egypt. No detailed studies have been carried out on these occurrences. Few previous studies documented the occurrence of gold-bearing listvenite in the vicinity of ophiolitic ultramafic masses commonly distributed along major thrust faults with gold values ranging from 0.01 to 6.8 g/t. In this respect, a detailed genetic model is needed to configure a reasonable mechanism of listvenitization taking into consideration the general tectonic setting, major and mesoscopic structures, place of metasomatism, and order of different types of alterations, in addition to mineralogical changes and geochemical modifications. The genetic model can be applied in exploring the numerous areas of ultramafic rocks in the Eastern Desert of Egypt. On the other hand, geophysical methods are increasingly utilized in mineral exploration for their efficiency in providing essential subsurface data, especially in challenging terrains with high relief or limited accessibility. The present chapter aims to investigate and set out a little on the role of magnetometry as an effective geophysical methodology in exploring listvenite associated with ophiolitic ultramafic rocks as a potential source of gold mineralization in the Eastern Desert of Egypt. The different new magnetic methods, conventional and non-conventional filters, are discussed and two case studies are presented. Results indicate that gold mineralization in various regions of the Eastern Desert and the Nubian Shield is linked to altered ultramafic zones, which are affected by faulting and shearing and show a low magnetic susceptibility anomaly.