The most life-threatening cancers affecting the eye include uveal and conjunctival melanomas, metastases, retinoblastoma, and vitreoretinal lymphoma. Patients with eye cancer are threatened with loss of vision, ocular pain, disfigurement, illness, and early death. All involved in cancer care need to understand their patients’ needs and fears as well as their coping mechanisms. Effective communication is essential. At such a stressful time, patients need good psychological support, not only from the ocular oncology team but also from their family and patient organizations. Self-help should also be encouraged. When it comes to speaking to children with cancer, the clinician should help parents to make the best decision for their family.