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Toxicology in the twenty-first century (Tox-21) is a multidisciplinary approach that combines high-throughput screening (HTS), in silico models, and omics tools, with the goal of quick and advanced toxicity assessments of organic pollutants in the marine environment. Tox-21 is used to predict the toxicity of legacy organic pollutants, including polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFAS), and polycyclic aromatic hydrocarbons (PAHs). The integration of Tox-21 with omics data enables the identification of important toxicity pathways and possible targets for risk assessment. This chapter focuses on the current methods for predicting toxicity of marine organic pollutants.

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Toxicity in the Twenty-First Century (Tox-21): A Multidisciplinary Approach for Toxicity Prediction of Marine Organic Pollutants

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  • 发表日期：

    2025年

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  • Rakia Manzoor

摘要

Toxicology in the twenty-first century (Tox-21) is a multidisciplinary approach that combines high-throughput screening (HTS), in silico models, and omics tools, with the goal of quick and advanced toxicity assessments of organic pollutants in the marine environment. Tox-21 is used to predict the toxicity of legacy organic pollutants, including polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFAS), and polycyclic aromatic hydrocarbons (PAHs). The integration of Tox-21 with omics data enables the identification of important toxicity pathways and possible targets for risk assessment. This chapter focuses on the current methods for predicting toxicity of marine organic pollutants.