This chapter analyzes the considerable influence of the COVID-19 pandemic on the rapid growth of e-commerce, highlighting a substantial rise in online consumer activity that has persisted even after the pandemic's conclusion. This article examines the significant impact of Artificial Intelligence (AI) on the retail and e-commerce sectors in the MENA area. It emphasizes the increase in online platform usage as a result of widespread internet access and smartphone ownership. The text explores the capacity and obstacles of artificial intelligence (AI) in improving operational effectiveness, customer support, and the customization of consumer encounters. The analysis focuses on ethical considerations, namely regarding data privacy and the requirement for informed consent in data utilization. In conclusion, it promotes a cooperative strategy including both humans and AI, with a focus on ethical principles, data protection, and the wider consequences of AI implementation in the retail sector. This method aims to encourage innovation, economic development, and societal advantages in the MENA area.