Co-simulation, essential for various domains, involves simulating systems with heterogeneous subsystems by combining them into scenarios using orchestration algorithms. Due to system evolutions, digital twins may require dynamic reconfiguration of the scenario and orchestration algorithm, which may introduce a significant simulation error that may go unnoticed if the scenario and orchestration algorithm are not correctly aligned. This paper introduces a monitor-based approach to automatically detect and help prevent any discrepancies between the scenario and the orchestration algorithm. The approach’s overhead may be significant for short simulations, but amortizes over longer simulations, as illustrated by a case study.