The e-commerce industry in Nigeria has been significantly influenced by the integration of Artificial Intelligence (AI) technology. While this innovative technology has presented new opportunities for advancement and development, it has equally elicited fears and concerns regarding the future relevance of humanity, particularly with the rising unemployment, poverty and inflation rates in Nigeria. Using the diffusion of innovation and the technology determinism theories, this chapter discusses the opportunities, challenges, and ethical considerations associated with deploying AI in the digital communication strategies of e-commerce companies, using three case studies of Konga, Jumia and Jiji. The chapter recommends that e-commerce companies integrate AI tools responsibly. These efforts will contribute to attaining Goal 9 of the 2030 SDG goals, which addresses the upgrading of technological facilities in the industries of developing countries, and ensuring the formulation of effective policies that support the sustainable growth and ethical integration of AI to the e-commerce industry.