QA application in dApps is an issue that every blockchain network faces because it is decentralized. This paper aims to analyze the correlation between Six Sigma, which is famous for its systematic approach to tackling organizational issues, and Hyperledger Fabric, which is a permission blockchain platform known for the security and scalability of the architecture it offers to support the enhancement of the QA processes within the context of healthcare when delivering and implementing dApps. Even though Six Sigma is introduced in the centralized organizational management model, this research aims to evaluate whether Six Sigma can be implemented in the decentralized nature of Blockchain. The implication of this research is enormous because it might change the quality assurance approach for decentralized applications. The applied study uses the DMAIC (Define, Measure, Analyze, Improve, Control) to identify and understand quality issues that arise during the creation and integration of dApps into the healthcare system. This integration will advance the field of Quality Assurance for decentralized applications to be more secure and scalable in health and disease control and monitoring, such as blood pressure, glucose level, and other records in health care initiated from intelligent wearable devices, giving a sense of confidence about the authenticity of the research.