Nursing is demanding and often clashes with family responsibilities causing significant Work-Family Conflict (WFC). Nurses have long shifts, emotionally demanding workloads, and deep patient involvement which strains their work-life balance. This conflict blurs the lines between work and home and depletes emotional resources leading to burnout symptoms: emotional exhaustion, depersonalization, and reduced accomplishment. Burnout happens when nurses try to juggle work demands with personal responsibilities, hence organizational support is needed. ICU and emergency environments are known to be high-stress and deeply impact nurses’ personal lives through WFC. This affects nurse health and family well-being, especially in the ICU setting. Perceived Organizational Support (POS) which is how valued and supported nurses feel by their employers plays a big role in mitigating these challenges. This study will look into how WFC contributes to burnout among ICU nurses and the buffering effect of POS. The study had 449 ICU nurses from private hospitals in India through simple random sampling. Surveys showed that WFC did not affect ICU nurses’ accomplishment but affected emotional exhaustion and depersonalization. POS was found to moderate these effects hence it plays a role in buffering burnout risk among ICU nurses. The results emphasized the need for strong organizational support in nursing administration to mitigate WFC and burnout. The study had 449 ICU nurses from private hospitals in India through simple random sampling. Surveys showed that work-family conflict did not affect ICU nurses’ accomplishment but affected emotional exhaustion and depersonalization. Perceived Organizational Support (POS) was found to moderate these effects hence it plays a big role in buffering burnout risk among ICU nurses. The results emphasized the need for strong organizational support in nursing administration to mitigate work-family conflict and burnout.